Congenital Zika Syndrome: Insights from Integrated Proteomic and Metabolomic Analysis.

ABSTRACT: Background: In this study, we investigated the role of extracellular vesicles (EVs) in the pathogenesis of Congenital Zika Syndrome (CZS). Previous studies have highlighted the role of EVs in intercellular communication and the modulation of biological processes during viral infections, motivating our in-depth analysis. Our objective was to identify specific molecular signatures in the EVs of patients with CZS, focusing on their potential as biomarkers and on cellular pathways affected by the infection. Methods: We conducted advanced proteomic and metabolomic analyses using mass spectrometry for protein and metabolite identification. EVs were isolated from CZS patient samples and control groups using Izon qEV size-exclusion chromatography columns. Results: The analyzed

SUBMITTER: Gomes-de-Pontes L 

PROVIDER: S-EPMC11762526 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature