GPIHBP1 increase accounts for rheumatic arthritis-related hypotriglyceridemia by facilitating lipids uptake of white adipose tissues.

ABSTRACT:

Background

Metabolism alteration is a common complication of rheumatic arthritis (RA). This work investigated the reason behind RA-caused triglyceride (TG) changes.

Methods

Fresh RA patients' whole blood was transfused into NOD-SCID mice. Metabolism-regulatory tissues were examined after sacrifice. To verify the findings, tissues of the rats with long-lasting adjuvant-induced arthritis (AIA) were analyzed. Some rats were injected with human plasma and GPIHBP1, and their blood TG was monitored. Various cells were stimulated by cytokines or rheumatic subjects' serum. Some pre-adipocytes were cultured by human serum or in the presence of HUVEC cells and GPIHBP1.

Results

TG decrease occurred in blood and white adipose tissues (WAT) of the RA blood-transfused NOD-SCID mice

SUBMITTER: Song MK 

PROVIDER: S-EPMC11762532 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature