Risk and Benefit for Basket Trials in Oncology: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Oncology research is increasingly adopting new clinical trial models that implement the concept of precision medicine. One of these is the basket clinical trial design. Basket clinical trials allow new treatments to be evaluated across multiple tumor types. Patients recruited to basket clinical trials share certain molecular characteristics of their cancer that are predictive of clinical benefit from the experimental treatment.

Objective

Our aim was to describe the risks and benefits of basket clinical trials in oncology.

Methods

Our study was prospectively registered in PROSPERO (CRD42023406401). We systematically searched PubMed, Embase, and ClinicalTrials.gov for reports of basket clinical trials in oncology published between 1 January, 2001, and 14 June

SUBMITTER: Klas K 

PROVIDER: S-EPMC11762573 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature