A Pooled Pharmacokinetic Analysis for Piperacillin/Tazobactam Across Different Patient Populations: From Premature Infants to the Elderly.

ABSTRACT:

Background and objectives

The pharmacokinetics (PK) of piperacillin/tazobactam (PIP/TAZ) is highly variable across different patient populations and there are controversies regarding non-linear elimination as well as the fraction unbound of PIP (f_{UNB_PIP}). This has led to a plethora of subgroup-specific models, increasing the risk of misusing published models when optimising dosing regimens. In this study, we aimed to develop a single model to simultaneously describe the PK of PIP/TAZ in diverse patient populations and evaluate the current dosing recommendations by predicting the PK/pharmacodynamics (PD) target attainment throughout life.

Methods

Population PK models were separately built for PIP and TAZ based on data from 13 studies in various patient populations

SUBMITTER: Kong D 

PROVIDER: S-EPMC11762590 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature