Cathodic tandem alkylation/dearomatization of heterocycles enabled by Al-facilitated carbonyl deoxygenation.

ABSTRACT: Developing efficient strategies for the deoxygenative functionalization of carbonyl compounds is crucial for enhancing the effective utilization of biomass and the upgrading of chemical feedstocks. In this study, we present an elegant cathodic reduction strategy that enables a tandem alkylation/dearomatization reaction between quinoline derivatives and aryl aldehydes/ketones in a one-pot process. Our approach can be executed via two distinct paths: the aluminum (Al)-facilitated spin-center shift (SCS) path and the Al-facilitated direct deoxygenation path. Both paths are theoretically substantiated by DFT calculations. The crux of this protocol is the in-situ activation of the alcohol intermediates by Al salts, which substantially lowers the activation energy necessary for the formation of

SUBMITTER: Hu J 

PROVIDER: S-EPMC11762781 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature