MOMAST^® Downregulates AQP3 Expression and Function in Human Colon Cells.

ABSTRACT: The water channel AQP3 is an aquaglyceroporin expressed in villus epithelial cells, and it plays a role in water transport across human colonic surface cells. Beyond water, AQP3 can mediate glycerol and H₂O₂ transport. Abnormal expression and function of AQP3 have been found in various diseases often characterized by altered cell growth and proliferation. Here, the beneficial effects of MOMAST^® have been evaluated. MOMAST^® is an antioxidant-patented natural phenolic complex obtained from olive wastewater (OWW) of the Coratina cultivar. Treatment of human colon HCT8 cells with MOMAST^® reduced cell viability. Confocal studies and Western Blotting analysis demonstrated that treatment with MOMAST^® significantly decreased the sta

SUBMITTER: Angelini I 

PROVIDER: S-EPMC11762842 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature