The developmental lipidome of Nippostrongylus brasiliensis.

ABSTRACT:

Background

Nippostrongylus brasiliensis-a nematode of rodents-is commonly used as a model to study the immunobiology of parasitic nematodes. It is a member of the Strongylida-a large order of socioeconomically important parasitic nematodes of animals. Lipids are known to play essential roles in nematode biology, influencing cellular membranes, energy storage and/or signalling.

Methods

The present investigation provides a comprehensive, untargeted lipidomic analysis of four developmental stages/sexes (i.e. egg, L3, adult female and adult male stages) of N. brasiliensis utilising liquid chromatography coupled to mass spectrometry.

Results

We identified 464 lipid species representing 18 lipid classes and revealed distinct stage-specific changes in lipid composition throu

SUBMITTER: Wang T 

PROVIDER: S-EPMC11762861 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature