"Actor-critic" dichotomous hyperactivation and hypoconnectivity in obsessive-compulsive disorder.

ABSTRACT: Dysfunctional response inhibition, mediated by the striatum and its connections, is thought to underly the clinical manifestations of obsessive-compulsive disorder (OCD). However, the exact neural mechanisms remain controversial. In this study, we undertook a novel approach by positing that a) inhibition is a dynamic construct inherently susceptible to numerous failures, which require error-processing, and b) the actor-critic framework of reinforcement learning can integrate neural patterns of inhibition and error-processing in OCD with their behavioural correlates. We invited nineteen adults with OCD and 21 age-matched healthy controls to perform an fMRI-adjusted stop-signal task. Then, we extracted brain activation and connectivity values regarding distinct task phases in the "actor" and

SUBMITTER: Araujo A 

PROVIDER: S-EPMC11762915 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature