Proof of concept study - alternative pharmacoprophylaxis for high-altitude pulmonary edema: A hospital-based randomized controlled trial.

ABSTRACT:

Background

High-altitude pulmonary edema (HAPE) is noncardiogenic pulmonary edema caused by exaggerated hypoxic pulmonary vasoconstriction and abnormally high pulmonary artery pressure. Some patients who develop HAPE have more chances to develop HAPE again on reinduction to high altitude (HA). This was a pilot project to look for a suitable drug (acetazolamide, nifedipine, or tadalafil) that could be used prophylactically in HAPE patients on reinduction to HA. The study incorporated a randomized, double-blind, placebo-controlled trial.

Method

One hundred and twenty serving personnel/previously healthy lowlanders, inducted to HA, thirty in each group, with history of one episode of clinically and radiologically diagnosed mild-to-moderate HAPE, were randomly distributed in the

SUBMITTER: George OS 

PROVIDER: S-EPMC11762934 | biostudies-literature | 2025 Jan-Feb

REPOSITORIES: biostudies-literature