Matrix metalloproteinase-9 upregulation in keratinocytes of oral lichen planus via c-Jun N-terminal kinase signaling pathway activation.

ABSTRACT:

Background/purpose

Oral lichen planus (OLP) is a chronic inflammatory disorder characterized by basement membrane disruption, which plays a crucial role in its pathogenesis. Matrix metalloproteinases (MMPs), a group of proteolytic enzymes, contribute to the degradation of the basement membrane. The specific MMPs secreted by keratinocytes in OLP lesions and relevant regulatory mechanisms are not fully understood. This study aimed to investigate the involvement of MMPs in OLP pathogenesis, focusing on their expression in keratinocytes and regulatory mechanisms.

Materials and methods

MMP mRNA expression in OLP epithelium was analyzed using RNA sequencing data obtained from the Gene Expression Omnibus (GEO) database. Mucosa samples from 30 OLP patients and 30 healthy cont

SUBMITTER: Jiang X 

PROVIDER: S-EPMC11762939 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature