Abnormal neural circuits and altered brain network topological properties in patients with persistent postural-perceptual dizziness.

ABSTRACT: Persistent Postural-Perceptual Dizziness (PPPD) is a common cause of chronic vestibular syndrome. Although previous studies have identified central abnormalities in PPPD, the specific neural circuits and the alterations in brain network topological properties, and their association with dizziness and postural instability in PPPD remain unclear. This study includes 30 PPPD patients and 30 healthy controls. Resting-state functional magnetic resonance imaging is used to construct whole-brain functional connectivity matrices, followed by network-based statistic and graph theoretical analysis. Network-based statistic results reveal an abnormal neural network in PPPD patients with key nodes in the occipital visual cortex, precuneus, sensorimotor cortex, multisensory vestibular cortex and cerebel

SUBMITTER: Li K 

PROVIDER: S-EPMC11762978 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature