Fluid flow impacts endothelial-monocyte interactions in a model of vascular inflammatory fibrosis.

ABSTRACT: The aberrant vascular response associated with tendon injury results in circulating immune cell infiltration and a chronic inflammatory feedback loop leading to poor healing outcomes. Studying this dysregulated tendon repair response in human pathophysiology has been historically challenging due to the reliance on animal models. To address this, our group developed the human tendon-on-a-chip (hToC) to model cellular interactions in the injured tendon microenvironment; however, this model lacked the key element of physiological flow in the vascular compartment. Here, we leveraged the modularity of our platform to create a fluidic hToC that enables the study of circulating immune cell and vascular crosstalk in a tendon injury model. Under physiological shear stress consistent with postcapill

SUBMITTER: Linares I 

PROVIDER: S-EPMC11763004 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature