Exploring the bidirectional causality between neuroticism and frailty: a Mendelian randomization analysis.

ABSTRACT:

Background

Epidemiological studies have confirmed the relationship between personality trait neuroticism and physical health. However, the relationship between neuroticism and frailty remains unconfirmed. This study employed a bi-directional two-sample Mendelian randomization (MR) approach to investigate the causal relationship between neuroticism and frailty.

Methods

The neuroticism genome-wide association study (GWAS) data from the UK Biobank contained twelve neuroticism-related traits with 489,212 participants. The genetic frailty index data were extracted from the UK Biobank and Swedish TwinGene, involving 175,226 individuals. Independent genetic variants associated with neuroticism and frailty were selected as instrumental variables. Inverse variance weighted (IVW), MR-

SUBMITTER: Xing Y 

PROVIDER: S-EPMC11763127 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature