Sperm DNA fragmentation index: limited effectiveness on predicting embryo quality in assisted reproduction technology treatments.

ABSTRACT:

Purpose

Prior sperm DNA fragmentation index (DFI) thresholds for diagnosing male infertility and predicting assisted reproduction technology (ART) outcomes fluctuated between 15 and 30%, with no agreed standard. This study aimed to evaluate the impact of the sperm DFI on early embryonic development during ART treatments and establish appropriate DFI cut-off values.

Methods

Retrospectively analyzed 913 couple's ART cycles from 2021 to 2022, encompassing 1,476 IVF and 295 ICSI cycles, following strict criteria. The WHO guidelines directed the semen analysis, while the acridine orange test (AOT) determined the DFI. Male factors (age, BMI, DFI, infertility duration, sperm parameters) and female parameters (age, BMI, AMH, retrieved oocytes) were evaluated. We also assessed embryo

SUBMITTER: Jiang H 

PROVIDER: S-EPMC11763148 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature