Bioabsorbable magnesium-based bulk metallic glass composite (BMGC) for improved medial opening wedge high tibial osteotomy in knee osteoarthritis.

ABSTRACT:

Background and objective

Osteoarthritis is a widespread and debilitating condition, particularly affecting the medial compartment of knee joint due to varus knee deformities. Medial opening wedge high tibial osteotomy (MOWHTO) has emerged as an effective treatment, but it comes with challenges like fractures, correction loss, and nonunion, leading to unsatisfactory results in up to 26 % of patients. In response, our study explores the potential of a bioabsorbable magnesium-based bulk metallic glass composite (Mg₆₇Zn₂₈Ca₅ BMGC) enriched with molybdenum particles as an innovative solution for MOWHTO.

Methods

Our comprehensive study includes composite fabrication, mechanical property evaluations, in vitro degradation tests, cell viability assess

SUBMITTER: Chen KH 

PROVIDER: S-EPMC11763224 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature