Microdifferential Pressure Measurement Device for Cellular Microenvironments.

ABSTRACT: Mechanical forces influence cellular proliferation, differentiation, tissue morphogenesis, and functional expression within the body. To comprehend the impact of these forces on living organisms, their quantification is essential. This study introduces a novel microdifferential pressure measurement device tailored for cellular-scale pressure assessments. The device comprises a glass substrate and a microchannel constructed of polydimethylsiloxane, polytetrafluoroethylene tubes, a glass capillary, and a microsyringe pump. This device obviates the need for electrical measurements, relying solely on the displacement of ultrapure water within the microchannel to assess the micropressure in embryos. First, the device was subjected to arbitrary pressures, and the relationship between the pressur

SUBMITTER: Akaike M 

PROVIDER: S-EPMC11763269 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature