Cardiovascular Risk Biomarkers in Women with and Without Polycystic Ovary Syndrome.

ABSTRACT:

Objective

Polycystic ovary syndrome (PCOS) is a prevalent metabolic disorder with an increased risk for cardiovascular disease (CVD) that is enhanced by obesity. This study sought to determine whether a panel of cardiovascular risk proteins (CVRPs) would be dysregulated in overweight/obese PCOS patients, highlighting potential biomarkers for CVD in PCOS.

Methods

In this exploratory cross-sectional study, plasma levels of 54 CVRPs were analyzed in women with PCOS (n = 147) and controls (n = 97). CVRPs were measured using the SOMAscan proteomic platform (version 3.1), with significant proteins identified through linear models, regression analysis, and receiver operating characteristic (ROC) analysis. Analysis on BMI-matched subsets of the cohort were undertaken. Functional enr

SUBMITTER: Nandakumar M 

PROVIDER: S-EPMC11763313 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature