Lupeol Attenuates Palmitate-Induced Hypertrophy in 3T3-L1 Adipocytes.

ABSTRACT: Obesity is characterized by the enlargement of adipose tissue due to an increased calorie intake exceeding the body's energy expenditure. Changes in the size of adipose tissue can lead to harmful consequences, with excessive fat accumulation resulting in adipocyte hypertrophy and promoting metabolic dysfunction. These adiposity-associated pathologies can be influenced by dietary components and their potential health benefits. Lupeol, a pharmacologically active pentacyclic triterpenoid found in medicinal plants, vegetables, and fruits, has been shown to exhibit antioxidant and anti-inflammatory properties. This study investigated the role of lupeol on adipocyte hypertrophy by evaluating key adipogenic regulators in vitro. First, 3T3-L1 MBX mouse embryonic cells were differentiated into adip

SUBMITTER: Selvaraju V 

PROVIDER: S-EPMC11763665 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature