Differential Response to Local Stimulator of Interferon Genes Agonist Administration in Tumors with Various Stimulator of Interferon Genes Statuses.

ABSTRACT: Background/Objectives: The stimulator of interferon genes (STING) is currently accepted as a relevant target for anti-cancer therapies. Besides encouraging results showing STING agonist-induced tumor growth inhibition, in some types of tumors the effect is less prominent. We hypothesized that higher STING levels in cancer cells and the possibility of its activation determine a greater anti-cancer response. As the local administration of STING agonists induces a systemic reaction, we emphasized the importance of host tumor-induced hematological disruption in the efficiency of the therapeutic response. Methods: We investigated the response to STING stimulation in murine cancer cell lines-melanoma (B16-F10) and breast carcinoma (4T1)-and murine normal cell lines: fibroblast cell

SUBMITTER: Drzyzga A 

PROVIDER: S-EPMC11763682 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature