Multiple Myeloma Cells Shift the Fate of Cytolytic ILC2s Towards TIGIT-Mediated Cell Death.

ABSTRACT:

Background

Growing evidence attests to the multifaceted roles of group 2 innate lymphoid cells (ILC2s) in cancer immunity. They exhibit either pro- or anticancer activity depending on tumor type but their function in Multiple Myeloma (MM) is still not elucidated.

Methods

The bone marrow (BM) and peripheral blood (PB) of patients (pts) with MM or precancerous conditions were collected, and specific properties of ILC2 subsets were assessed by flow cytometry.

Results

By dissecting ILC2s according to c-Kit marker, we observed that NKp30 and NKG2D were mainly confined to c-Kit^hi ILC2s, while levels of DNAM-1 was significantly higher in fully mature c-Kit^lo cells. Among the total MM-associated ILC2s (MM-ILC2s), we observed a significant increase in c-t

SUBMITTER: Drommi F 

PROVIDER: S-EPMC11763689 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature