Resonant Young's Slit Interferometer for Sensitive Detection of Low-Molecular-Weight Biomarkers.

ABSTRACT: The detection of low-molecular-weight biomarkers is essential for diagnosing and managing various diseases, including neurodegenerative conditions such as Alzheimer's disease. A biomarker's low molecular weight is a challenge for label-free optical modalities, as the phase change they detect is directly proportional to the mass bound on the sensor's surface. To address this challenge, we used a resonant Young's slit interferometer geometry and implemented several innovations, such as phase noise matching and optimisation of the fringe spacing, to maximise the signal-to-noise ratio. As a result, we achieved a limit of detection of 2.9 × 10^-6 refractive index units (RIU). We validated our sensor's low molecular weight capability by demonstrating the detection of Aβ-42, a 4.5 kDa p

SUBMITTER: Wijaya SR 

PROVIDER: S-EPMC11763694 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature