PLASMA: Partial LeAst Squares for Multiomics Analysis.

ABSTRACT: Background/Objectives: Recent growth in the number and applications of high-throughput "omics" technologies has created a need for better methods to integrate multiomics data. Much progress has been made in developing unsupervised methods, but supervised methods have lagged behind. Methods: Here we present the first algorithm, PLASMA, that can learn to predict time-to-event outcomes from multiomics data sets, even when some samples have only been assayed on a subset of the omics data sets. PLASMA uses two layers of existing partial least squares algorithms to first select components that covary with the outcome and then construct a joint Cox proportional hazards model. Results: We apply PLASMA to the stomach adenocarcinoma (STAD) data from The Cancer Genome Atlas. We v

SUBMITTER: Yamaguchi K 

PROVIDER: S-EPMC11763701 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature