Cross-Sectional Analysis of IL-6, TNF-α, Adiponectin, Leptin, and Klotho Serum Levels in Relation to BMI Among Overweight and Obese Children Aged 10-14 in La Rioja, Spain.

ABSTRACT:

Background

Childhood obesity is a major public health concern, being linked to an increased risk of metabolic disorders and cardiovascular disease. Even in childhood, obesity is associated with systemic low-grade inflammation, which is a critical factor in the development of atherosclerosis and a predictor of cardiovascular morbidity and mortality.

Objectives

To describe the prevalence of obesity and examine the relationship between IL-6, TNF-α, adiponectin, leptin, the leptin/adiponectin (L/A) ratio, and Klotho levels with BMI in children.

Methods

This cross-sectional study included children aged 10-14 years from La Rioja, Spain. Participants were selected based on BMI criteria for overweight (85th-95th percentiles) and obesity (>95th percentile). Socio-demographic a

SUBMITTER: Fernandez-Vallejo B 

PROVIDER: S-EPMC11763806 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature