Effect of Kinases in Extracellular Vesicles from HIV-1-Infected Cells on Bystander Cells.

ABSTRACT: As of 2023, there were 39.9 million people living with Human Immunodeficiency Virus type 1 (HIV-1). Although great strides have been made in treatment options for HIV-1, and our understanding of the HIV-1 life cycle has vastly improved since the start of this global health crisis, a functional cure remains elusive. One of the main barriers to a cure is latency, which allows the virus to persist despite combined antiretroviral therapy (cART). Recently, we have found that exosomes, which are small, membrane-enclosed particles released by virtually all cell types and known to mediate intercellular communication, caused an increase in RNA Polymerase II loading onto the HIV-1 promoter. This resulted in the production of both short- and long-length viral transcripts in infected cells under cART.

SUBMITTER: Mensah GA 

PROVIDER: S-EPMC11763833 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature