Previous treatment with anthracycline does not affect the course of sepsis in cancer patients: Retrospective cohort study.

ABSTRACT:

Background

Cancer patients who are exposed to sepsis and had previous chemotherapy may have increased severity. Among chemotherapeutic agents, anthracyclines have been associated with cardiac toxicity. Like other chemotherapeutic agents, they may cause endothelial toxicity. The aim of this study was to evaluate the effect of anthracycline treatment on the outcome of cancer patients with sepsis.

Methods

Data from cancer patients admitted to intensive care units (ICUs) for sepsis or septic shock were extracted from the Groupe de Recherche Respiratoire en Réanimation Onco-Hématologique database (1994-2015). Comparison between patients who received anthracycline and those who did not was performed using a propensity score, including confounding variables (age and underlying dise

SUBMITTER: Windsor C 

PROVIDER: S-EPMC11763860 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature