SPR Biosensor Based on Bilayer MoS₂ for SARS-CoV-2 Sensing.

ABSTRACT: The COVID-19 pandemic has highlighted the urgent need for rapid, sensitive, and reliable diagnostic tools for detecting SARS-CoV-2. In this study, we developed and optimized a surface plasmon resonance (SPR) biosensor incorporating advanced materials to enhance its sensitivity and specificity. Key parameters, including the thickness of the silver layer, silicon nitride dielectric layer, molybdenum disulfide (MoS₂) layers, and ssDNA recognition layer, were systematically optimized to achieve the best balance between sensitivity, resolution, and attenuation. The optimized configuration, consisting of a 45 nm silver layer, a 13 nm silicon nitride layer, 2 MoS₂ layers, and a 5 nm ssDNA layer, demonstrated superior performance for detecting SARS-CoV-2 in PBS solution. The

SUBMITTER: Tene T 

PROVIDER: S-EPMC11763928 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature