<i>CYP24A1</i> DNA Methylation in Colorectal Cancer as Potential Prognostic and Predictive Markers.

ABSTRACT: The DNA methylation of CYP24A1 can regulate its gene expression and may play a role in the occurrence and progression of colorectal cancer (CRC). However, the association between CYP24A1 DNA methylation and the prognosis of CRC patients has not yet been reported. In this study, differential methylation analysis was conducted in both blood and tissue cohorts, and differential expression analysis was performed in the tissue cohort with in vitro validation. GO and KEGG enrichment analyses were performed on CYP24A1-related genes. A correlation between CYP24A1 promoter methylation and its gene expression was explored. Kaplan-Meier survival and Cox regression analyses were performed to investigate the impact of CYP24A1 DNA methylation on the prognosis of CRC pa

SUBMITTER: Zhou RH 

PROVIDER: S-EPMC11763947 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature