Diagnostic Performance of PIVKA-II in Italian Patients with Hepatocellular Carcinoma.

ABSTRACT:

Background and aims

Hepatocellular carcinoma (HCC) represents the second leading cause of cancer deaths worldwide. Six-month imaging along with alpha-fetoprotein (AFP) serum levels detection are the current gold standard to exclude HCC. Protein induced by vitamin K absence (PIVKA-II) has been proposed as a potential screening biomarker for HCC. This study was designed to evaluate the role of PIVKA-II as diagnostic HCC marker, and the correlation between PIVKA-II levels and HCC stage.

Methods

PIVKA-II levels were assessed on serum samples of Italian patients. The study population included 80 patients with HCC, 111 with liver cirrhosis (LC), and 111 with chronic hepatitis C (CHC).

Results

PIVKA-II serum levels progressively increase from patients with CHC to patients wi

SUBMITTER: Guarneri V 

PROVIDER: S-EPMC11763969 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature