Theranostic Contact Lens for Ocular Cystinosis Utilizing Gold Nanoparticles.

ABSTRACT: Ocular cystinosis is a disease in which accumulated cystine crystals cause damage to the eyes, necessitating timely treatment and ongoing monitoring of cystine levels. The current treatment involves frequent administration of cysteamine eye drops, which suffer from low bioavailability and can lead to drug toxicity, making it essential to prescribe an appropriate dosage based on the patient's condition. Additionally, cystine crystal levels are typically assessed subjectively via slit-lamp examination, requiring frequent clinical visits and causing discomfort for the patient. In this study, we propose a theranostic contact lens that simultaneously performs therapy and diagnosis on a single platform utilizing gold nanoparticles (GNPs). The binding interactions between GNPs and cystine were co

SUBMITTER: Ha E 

PROVIDER: S-EPMC11764065 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature