Ginsenoside Rc prevents dexamethasone-induced muscle atrophy and enhances muscle strength and motor function.

ABSTRACT:

Background

A decline in muscle mass and function can impact the health, disease vulnerability, and mortality of older adults. Prolonged use of high doses of glucocorticoids, such as dexamethasone (DEX), can cause muscle wasting and reduced strength. Ginsenoside Rc (gRc) has been shown to protect muscles by activating the PGC-1α pathway and improving mitochondrial function. The effects of gRc on muscle atrophy and function in mice are not fully understood.

Methods and results

The study discovered that gRc prevented the DEX-induced decrease in viability of C2C12 myoblasts and myotubes. Furthermore, gRc inhibited myotube degradation and the upregulation of muscle degradation proteins induced by DEX. Transcriptome analysis of myotubes showed that gRc enhances muscle generation p

SUBMITTER: Kim A 

PROVIDER: S-EPMC11764205 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature