Cerebellar Volume Measures Differentiate Multiple Sclerosis Fallers from Non-Fallers.

ABSTRACT:

Introduction

The cerebellum is a common lesion site in persons with multiple sclerosis (PwMS). Physiologic and anatomic studies have identified a topographic organization of the cerebellum including functionally distinct motor and cognitive areas. In this study, a recent parcellation algorithm was applied to a sample of PwMS and healthy controls to examine the relationships among specific cerebellar regions, fall status, and common clinical measures of motor and cognitive functions.

Methods

Thirty-one PwMS and twenty-nine age- and sex-matched controls underwent an MRI scan and motor and cognitive testing. The parcellation algorithm was applied to all images and divided the cerebellum into 28 regions. Mann-Whitney U tests were used to compare cerebellar volumes among PwMS and

SUBMITTER: Takla TN 

PROVIDER: S-EPMC11764211 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature