Melanoma extracellular vesicles membrane coated nanoparticles as targeted delivery carriers for tumor and lungs.

ABSTRACT: Targeting is the most challenging problem to solve for drug delivery systems. Despite the use of targeting units such as antibodies, peptides and proteins to increase their penetration in tumors the amount of therapeutics that reach the target is very small, even with the use of nanoparticles (NPs). Nature has solved the selectivity problem using a combination of proteins and lipids that are exposed on the cell membranes and are able to recognize specific tissues as demonstrated by cancer metastasis. Extracellular vesicles (EVs) have a similar ability in target only certain organs or to return to their original cells, showing home behavior. Here we report a strategy inspired by nature, using a combination of NPs and the targeting cell membranes of EVs. We implement the EV membranes, extrac

SUBMITTER: Sancho-Albero M 

PROVIDER: S-EPMC11764275 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature