Molecular Epidemiology and In-Depth Characterization of <i>Klebsiella pneumoniae</i> Clinical Isolates from Armenia.

ABSTRACT: The global dissemination of Klebsiella pneumoniae pathotypes with multidrug-resistant (MDR) and hypervirulent traits poses a threat to public health. The situation in Armenia is unclear, and we performed a comprehensive characterisation of 48 clinical isolates of K. pneumoniae, collected from 2018 to 2024. The majority of the isolates (64.58%) were extensively drug-resistant (XDR) and MDR. Genomic analysis of 21 isolates revealed the presence of international high-risk MDR clones (ST395, ST15, and ST307). The ST395 strains were isolated from children and resisted the first-line drugs such as beta-lactams. These isolates harboured a range of virulence determinants, from capsule polysaccharides to siderophores to regulators of the mucoid phenotype. The ST395 strains are enriche

SUBMITTER: Sedrakyan A 

PROVIDER: S-EPMC11764700 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature