Dysregulation of FURIN and Other Proprotein Convertase Genes in the Progression from HPV Infection to Cancer.

ABSTRACT: Productive infections of oncogenic human papillomaviruses (HPVs) are closely linked to the differentiation of host epithelial cells, a process that the virus manipulates to create conditions favorable to produce virion progeny. This viral interference involves altering the expression of numerous host genes. Among these, proprotein convertases (PCs) have emerged as potential oncogenes due to their central role in cellular functions. Using RT-qPCR, aberrant PC gene expression was detected across the progression from early HPV infection stages to cancer. These findings demonstrated a progressive disruption of normal PC expression profiles, with FURIN consistently downregulated and other PCs upregulated, transitioning from the episomal stage to neoplastic and carcinoma phenotypes. This pattern

SUBMITTER: Izaguirre G 

PROVIDER: S-EPMC11764867 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature