Effect and mechanism of Sanqi () in treating periodontitis.

ABSTRACT:

Objective

To investigate the effect and mechanism of Sanqi (Radix Notoginseng) in treating periodontitis.

Methods

The active components and periodontitis targets were analyzed through network pharmacology and molecular docking. A rat model of periodontitis was established and rats were treated by continuous intragastric administration of Sanqi (Radix Notoginseng) at different doses for 30 d. The alveolar bone structure was observed by micro-CT, the periodontal tissue structure was observed by hematoxylin-eosin staining, and the related proteins changes was detected by immunohistochemical staining.

Results

Sanqi (Radix Notoginseng) and periodontitis had a total of 96 coincident targets that were significantly enriched in the interleukin 17 (IL-17),

SUBMITTER: Yuanyuan AN 

PROVIDER: S-EPMC11764944 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature