Electroacupuncture alleviates zymosan-induced colorectal hypersensitivity.

ABSTRACT:

Objective

this study to investigate the mechanism underlying the electroacupuncture (EA) alleviates colorectal hypersensitivity, a feature of irritable bowel syndrome (IBS).

Methods

The colorectal hypersensitivity model was established by treating mice with zymosan. Electrophysiological techniques, Western blotting and immunofluorescence staining were used to detect the changes of the sensitive state of the colorectum and the response in spinal ganglion and spinal cord after acupuncture intervention.

Results

colorectal distension studies revealed that repetitive applied electroacupuncture treatment on mice could significant alleviates colorectal intensity. Western blotting studies with nerve growth factor (NGF) in the colorectum, substance P (SP) in the spinal ganglio

SUBMITTER: Siting LI 

PROVIDER: S-EPMC11764946 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature