Pan-Cancer Upregulation of the <i>FOXM1</i> Transcription Factor.

ABSTRACT:

Background

The human FOXM1 transcription factor controls cell cycle progression and genome stability, and it has been correlated to the onset and progression of many tumor types.

Methods

In our study, we collected all recent sequence and quantitative transcriptomics data about FOXM1, testing its presence across vertebrate evolution and its upregulation in cancer, both in bulk tissue contexts (by comparing the TCGA tumor dataset and the GTEx normal tissue dataset) and in single-cell contexts.

Results

FOXM1 is significantly and consistently upregulated in all tested tumor types, as well as in tumor cells within a cancer microenvironment. Its upregulation reverberates in the upregulation of its target genes and can be used as a biomarker for poor can

SUBMITTER: Pozzobon D 

PROVIDER: S-EPMC11765198 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature