Sequential Obtention of Blood-Brain Barrier-Permeable Non-Polar and Polar Compounds from <i>Salvia officinalis</i> L. and <i>Eucalyptus globulus</i> Labill. with Neuroprotective Purposes.

ABSTRACT: This study investigates the biorefinery approach to extracting blood-brain barrier (BBB)-permeable compounds from Eucalyptus globulus Labill. and Salvia officinalis L. for neuroprotective purposes. A sequential extraction process was applied, starting with supercritical CO₂ extraction (SC-CO₂) to obtain non-polar terpenoids, followed by pressurized natural deep eutectic solvent extraction (PLE-NaDES) to recover phenolic compounds from the SC-CO₂ residue. PLE-NaDES extracts exhibited higher antioxidant and anticholinergic capacities than SC-CO₂ extracts for both plants, with S. officinalis extracts being more bioactive than E. globulus extracts. A total of 21 terpenoids were identified using gas chromatography-mass spec

SUBMITTER: Romano E 

PROVIDER: S-EPMC11765258 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature