Metallothionein-1A (MT1A) Gene Variability May Play a Role in Female Frailty: A Preliminary Study.

ABSTRACT:

Background/objectives

Frailty is a complex geriatric syndrome resulting in decreased physiological reserve. While genetics plays a role, the underlying mechanisms remain unsolved. Metallothioneins (MTs), metal-binding proteins with high affinity for zinc, an essential mineral for many physiological functions, are involved in processes including oxidative stress and inflammation. We investigated the impact of genetic variations in MTs on frailty.

Methods

448 subjects (235 females and 213 males, median age of 76 years) were categorized into three frailty groups (non-frail/pre-frail/frail), by hierarchical cluster analysis based on cognitive status (MMSE), functional capacity (ADL), and physical strength (HGS). Subjects were analyzed for selected SNPs in MT1A, MT1B

SUBMITTER: Crocco P 

PROVIDER: S-EPMC11765288 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature