The Prognostic Significance of TRs in Hepatocellular Carcinoma: Insights from TCGA and GEO Databases.

ABSTRACT:

Background

Reduced expression of thyroid hormone receptors (TRs) has been observed in various human malignancies, though its predictive value in hepatocellular carcinoma (HCC) remains uncertain.

Objective

To explore the predictive value of TRs in patients with hepatocellular carcinoma.

Design

The design was bioinformatic analysis combined with experimental study.

Methods

This study utilized Kaplan-Meier analysis of TR expression profiles from The Cancer Genome Atlas (TCGA). Expression levels of TRs in HCC and immune single cells were assessed using datasets from the Gene Expression Omnibus (GEO) and TCGA, analyzed with R software. Cox and logistic regression analyses were also conducted. Functional assays, including wound healing, CCK-8, and Transwell migration

SUBMITTER: Zhou H 

PROVIDER: S-EPMC11765354 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature