Model Organisms in Aging Research: Evolution of Database Annotation and Ortholog Discovery.

ABSTRACT:

Background

This study aims to analyze the exploration degree of popular model organisms by utilizing annotations from the UniProtKB (Swiss-Prot) knowledge base. The research focuses on understanding the genomic and post-genomic data of various organisms, particularly in relation to aging as an integral model for studying the molecular mechanisms underlying pathological processes and physiological states.

Methods

Having characterized the organisms by selected parameters (numbers of gene splice variants, post-translational modifications, etc.) using previously developed information models, we calculated proteome sizes: the number of possible proteoforms for each species. Our analysis also involved searching for orthologs of human aging genes within these model species.

Resu

SUBMITTER: Sarygina E 

PROVIDER: S-EPMC11765380 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature