Nrf2 Regulates Basal Glutathione Production in Astrocytes.

ABSTRACT: Astrocytes produce and export glutathione (GSH), an important thiol antioxidant essential for protecting neural cells from oxidative stress and maintaining optimal brain health. While it has been established that oxidative stress increases GSH production in astrocytes, with Nrf2 acting as a critical transcription factor regulating key components of the GSH synthetic pathway, the role of Nrf2 in controlling constitutive GSH synthetic and release mechanisms remains incompletely investigated. Our data show that naïve primary mouse astrocytes cultured from the cerebral cortices of Nrf2 knockout (Nrf2^-/-) pups have significantly less intracellular and extracellular GSH levels when compared to astrocytes cultured from Nrf2 wild-type (Nrf2^+/+) pups. Key components of the GSH

SUBMITTER: He J 

PROVIDER: S-EPMC11765531 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature