The Effect of Surface Functionalization of Magnesium Alloy on Degradability, Bioactivity, Cytotoxicity, and Antibiofilm Activity.

ABSTRACT: Magnesium alloys are promising biomaterials to be used as temporary implants due to their biocompatibility and biodegradability. The main limitation in the use of these alloys is their rapid biodegradation. Moreover, the risk of microbial infections, often following the implant surgery and hard to eradicate, is another challenge. Thus, with the aim of reducing biodegradability and conferring antibiofilm activity, sheets of the magnesium alloy AZ31 were properly modified with the introduction of hydroxy (polyethyleneoxy)propyl silane (PEG) and quaternary ammonium silane chains (QAS). The derivatized sheets were characterized by ATR-FTIR spectroscopy and their performances as concerns their stability, Mg²⁺ in vitro release, and in vitro bioactivity were evaluated as well. The resu

SUBMITTER: Nocchetti M 

PROVIDER: S-EPMC11765666 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature