In Vitro Insights into Bacteriocin-Mediated Modulation of Chicken Cecal Microbiota.

ABSTRACT: Reducing the use of antibiotics in animal husbandry is essential to limit the spread of resistance. A promising alternative to antibiotics resides in bacteriocins, which are antimicrobial peptides produced by bacteria showing a great diversity in terms of spectrum of activity, structure, and mechanism of action. In this study, the effects of diverse bacteriocins on the composition and metabolic activity of chicken cecal microbiota were examined in vitro, in comparison with antibiotics. Different impacts on microbiota composition were revealed by 16S metabarcoding, with colistin having the most dramatic impact on diversity. Bacteriocins produced by Gram-negative bacteria, microcins J25 and E492, did not significantly influence the microbiota composition. In contrast, bacteriocins from Gram-

SUBMITTER: Mamjoud A 

PROVIDER: S-EPMC11765717 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature