Proteins and DNA Sequences Interacting with Tanshinones and Tanshinone Derivatives.

ABSTRACT: Tanshinones, biologically active diterpene compounds derived from Salvia miltiorrhiza, interact with specific proteins and DNA sequences, influencing signaling pathways in animals and humans. This study highlights tanshinone-protein interactions observed at concentrations achievable in vivo, ensuring greater physiological relevance compared to in vitro studies that often employ supraphysiological ligand levels. Experimental data suggest that while tanshinones interact with multiple proteomic targets, only a few enzymes are significantly affected at biologically relevant concentrations. This apparent paradox may be resolved by tanshinones' ability to bind DNA and influence enzymes involved in gene expression or mRNA stability, such as RNA polymerase II and human antigen R protein. Th

SUBMITTER: Szymczyk P 

PROVIDER: S-EPMC11765770 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature