Clinical relevance of macromolecular complexes involving integrins, potassium and sodium ion channels and the sodium/proton antiporter in human breast cancer.

ABSTRACT:

Background

Mounting evidence underline the relevance of macromolecular complexes in cancer. Integrins frequently recruit ion channels and transporters within complexes which behave as signaling hubs. A complex composed by β1 integrin, hERG1 K⁺ channel, the neonatal form of the Na⁺ channel Na_V 1.5 (nNa_V1.5) and the Na⁺/H⁺ antiporter NHE1 (NHE1/hERG1/β1/nNa_V1.5 complex) has been recently described to be expressed and regulate relevant cancer related behaviors in Breast Cancer (BCa) cells.

Methods

We analyzed the expression and impact on outcome of the genes encoding the four proteins forming the NHE1/hERG1/β1/nNa_V1.5 complex (SLC9A1, KCNH2, ITGB1 and SCN5A) in public datasets. The correspon

SUBMITTER: Lastraioli E 

PROVIDER: S-EPMC11765915 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature