Identification of Downregulated <i>MECR</i> Gene in Parkinson's Disease Through Integrated Transcriptomic Analysis and Validation.

ABSTRACT: Parkinson's disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuron degeneration and α-synuclein (α-syn) aggregation. Lipid metabolism dysfunction may contribute to PD progression. This study aims to identify lipid metabolism-related genes (LMGs) associated with PD using an integrative transcriptomic analysis of microarray and single-cell RNA sequencing (scRNA-seq) datasets from patients with PD and healthy controls. Differentially expressed genes (DEGs) related to lipid metabolism were identified, and key genes were further filtered using weighted gene co-expression network analysis (WGCNA) and machine learning algorithms. Four LMGs, AGPAT2, ASAH2, FA2H, and MECR were identified, with MECR being notably downregulated in both bul

SUBMITTER: Wang D 

PROVIDER: S-EPMC11765974 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature