Analysis of Preventive Effect of Bisphosphonate for Osteoporotic Fracture in Patients with Alzheimer's Disease and Patient Mortality.

ABSTRACT: Background: Alzheimer's disease (AD) is the most common neurodegenerative disease in the older adult population and is often associated with reduced physical activity. Reduced activity and mechanical loading subsequently reduce bone mineral density and increase risk of osteoporosis. Bisphosphonates (BPs) offer preventative effects on osteoporotic fractures in the general population, but their effects on patients with AD are less known. This study aimed to assess the impact of BPs on osteoporotic fractures and survival in patients with AD. Methods: In this nationwide retrospective cohort study, 43,469 patients from the Korea National Health Insurance Service database between 2004 and 2018 were included. All patients were diagnosed with AD and subsequently diagnosed with osteop

SUBMITTER: Jang MU 

PROVIDER: S-EPMC11766000 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature