Model-Assisted Spleen Contouring for Assessing Splenomegaly in Myelofibrosis: A Fast and Reproducible Approach to Evaluate Progression and Treatment Response.

ABSTRACT: Background/Objectives: Accurate and reproducible spleen volume measurements are essential for assessing treatment response and disease progression in myelofibrosis. This study evaluates techniques for measuring spleen volume on abdominal MRI. Methods: In 20 patients with bone marrow biopsy-proven myelofibrosis, 5 observers independently measured spleen volume on 3 abdominal MRI pulse sequences, 3D-spoiled gradient echo T1, axial single-shot fast spin echo (SSFSE) T2, and coronal SSFSE T2, using ellipsoidal approximation, manual contouring, and 3D nnU-Net model-assisted contouring comparing coefficients of variation. Changes in spleen volume were compared to all information to assess which measurement technique tracked disease progression with the greatest accuracy. Results

SUBMITTER: Sharbatdaran A 

PROVIDER: S-EPMC11766003 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature