Enhancing the Solubility and Dissolution of Apigenin: Solid Dispersions Approach.

ABSTRACT: Apigenin (APG), a bioactive flavonoid with promising therapeutic potential, suffers from poor water solubility, which limits its bioavailability. To address this, solid dispersions of APG were prepared using ball milling with sodium alginate (SA), Pluronic^® F-68 (PLU68), Pluronic^® F-127 (PLU127), PVP K30, and PVP VA64 as polymeric excipients. These dispersions were screened for apparent solubility in water and buffers with pH 1.2, 5.5, and 6.8. Based on improved solubility after 60 min, APG-PLU68 and APG-PLU127 dispersions were selected for further study. DSC and FT-IR analysis confirmed molecular interactions between APG and the polymer matrices, contributing to enhanced solubility and dissolution rates. Dissolution rate studies showed that APG-PLU127 achieved 100% s

SUBMITTER: Rosiak N 

PROVIDER: S-EPMC11766082 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature